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Cleveland Clinic: New policies would expand pediatric lung transplant access, study shows

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Monday, Nov. 2, 2015, Cleveland: Broader geographic sharing of pediatric donor lungs could result in twice as many lung transplants for young patients in the U.S., according to a study published today in the American Journal of Transplantation.

Maryam Valapour, M.D., senior lung investigator for the Scientific Registry of Transplant Recipients (SRTR) and director of Lung Transplant Outcomes at Cleveland Clinic, is the senior author. The SRTR is the organization responsible for analyzing U.S. transplant data.

"Children are dying while waiting for an organ. Geography should be one less barrier to pediatric patients receiving a potentially life-saving transplant," Dr. Valapour said. "We believe these changes will give young patients more access to transplants and will result in organs getting to the sickest patients first."

The research team tested four alternatives to the current pediatric lung allocation system that were designed to improve pediatric access to donor lungs. The Organ Procurement and Transplantation Network (OPTN), which is responsible for making transplant policy, is currently reviewing the simulations and will choose one of them to be the new U.S. policy for pediatric lung allocation.

In the four alternative allocation models, adolescent donors and candidates were defined as ages 12 to 17, and children were under age 12. Adults are aged 18 and older. Under current allocation rules, donors and candidates are first matched based on geographic region and age.

Currently, donor lungs are first offered to candidates near the donor hospital. If no local candidates are identified, the donor lungs are offered beyond the local region in 500-mile radius increments. Child candidates receive priority for child donor lungs within a 1000-mile radius of the donor (followed by adolescents, then adults), and adolescent candidates receive priority for adolescent donor lungs (followed by children, then adults).

The research team studied models of wider geographic sharing of pediatric donor lungs to increase pediatric access to transplant using the thoracic simulated allocation model (TSAM), a program that uses actual candidates and donors to create recipients of simulated organ availability. The cohort included 5,907 lung and 141 heart-lung candidates listed for transplant between July 2009 and June 2011.

Two of the alternative allocation models resulted in significantly more transplants for pediatric patients. One of those focused on broader geographic sharing of adolescent and child donor lungs by offering adolescent donor lungs to adolescents, then to child candidates from the local region up to a 1,000-mile radius before offering them to local adults. It also allows child donor lungs to be offered preferentially to child candidates and then to adolescents within a 1,000-mile radius before adults are considered. This model more than doubled the amount of adolescent transplants, from 461 adolescent transplants per 100 patient-years on the waiting list, compared with 206 under current rules.

The other model prioritized child candidates over adolescents for adolescent donor lungs and broadened child access to adolescent donor lungs from the local region to a 1,000-mile radius. It resulted in 388 adolescent transplants per 100 patient-years on the waiting list and likely increased transplant rates for children.

Adult transplant rates, wait-list mortality and 1-year post-transplant mortality were not adversely affected in either of the alternative models. In 2014, 45 patients under the age of 18 received lung transplants.

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This research was a collaborative effort between SRTR and the OPTN Thoracic Committee. SRTR and OPTN are contracted by the Health Resources and Services Administration (HRSA), and the study was performed under that contract.

About Cleveland Clinic

Cleveland Clinic is a nonprofit multispecialty academic medical center that integrates clinical and hospital care with research and education. Located in Cleveland, Ohio, it was founded in 1921 by four renowned physicians with a vision of providing outstanding patient care based upon the principles of cooperation, compassion and innovation. Cleveland Clinic has pioneered many medical breakthroughs, including coronary artery bypass surgery and the first face transplant in the United States. U.S.News & World Report consistently names Cleveland Clinic as one of the nation's best hospitals in its annual "America's Best Hospitals" survey. More than 3,000 full-time salaried physicians and researchers and 11,000 nurses represent 120 medical specialties and subspecialties. The Cleveland Clinic health system includes a main campus near downtown Cleveland, eight community hospitals, more than 75 Northern Ohio outpatient locations, including 16 full-service Family Health Centers, Cleveland Clinic Florida, the Lou Ruvo Center for Brain Health in Las Vegas, Cleveland Clinic Canada, and Cleveland Clinic Abu Dhabi. In 2013, there were 5.5 million outpatient visits throughout the Cleveland Clinic health system and 157,000 hospital admissions. Patients came for treatment from every state and from more than 130 countries. Visit us at http://www.clevelandclinic.org. Follow us at http://www.twitter.com/ClevelandClinic.

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