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Chemotherapy may boost immunotherapy power in ovarian cancer

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Women with advanced ovarian cancer may benefit more from immunotherapy drug treatments if they are given straight after chemotherapy, according to a new study published in Clinical Cancer Research* today.

Researchers – funded by Cancer Research UK** and based at Queen Mary University London – examined samples from 60 women *** with ovarian cancer and found that chemotherapy given prior to surgery activates specialised immune cells called T cells within the tumour.

But they found that this also had a drawback. While the chemotherapy activated T cells it also boosted the cancer's defences against immune attack – cancers had higher levels of a protein called PD-L1 that stops T cells from recognising and destroying cancer cells.

The research findings suggest that drugs that boost the immune system would be most effective if given after chemotherapy and the most effective immunotherapy treatments will have to block the PD-L1 protein to allow T cells to target the tumour most effectively.

Lead author Professor Frances Balkwill, based at the Barts Cancer Institute at Queen Mary University of London, said: "Our study suggests that to give patients the best results not only do the immunotherapy drugs need to be given straight after chemotherapy but they also have to able to block PD-L1. Clinical trials are now needed to test this theory. This same approach could also be extended to other kinds of cancer where the same types of chemotherapy are used, such as lung cancer."

The study also revealed that women who did not respond well to chemotherapy still had increased levels of T cells suggesting that this type of immunotherapy could help treat all patients whether or not they had responded to chemotherapy.

Each year around 7,300 women are diagnosed with ovarian cancer and long term survival**** remains just 35 per cent.

Professor Peter Johnson, Cancer Research UK's chief clinician, said: "Treating advanced ovarian cancer is difficult, and in many women unfortunately the cancer returns after initial surgery and chemotherapy treatments. We urgently need new treatments to change this. This interesting information about how the immune system may change after chemotherapy may point us to the best way of using new immunotherapy drugs in ovarian cancer."

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Notes to editor:

*Bohm, S. et al Neoadjuvant chemotherapy modulates the immune microenvironment in metastases of tubo-ovarian high-grade serous carcinoma Clinical Cancer Research (2016)

**The study also received funding from the Swiss Cancer League, the European Research Council, and Barts and the London Charity.

***The researchers examined biopsies and blood samples from 60 women with high grade serous ovarian cancer – 54 who had platinum based chemotherapy prior to surgery and six who just had surgery.

****35 per cent of women survive their disease for 10 or more years: http://www.cancerresearchuk.org/health-professional/cancer-statistics/statistics-by-cancer-type/ovarian-cancer

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Simon Shears
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@CR_UK

http://www.cancerresearchuk.org

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