Tuesday, July 5, 2022
SCIENMAG: Latest Science and Health News
No Result
View All Result
  • Login
  • HOME PAGE
  • BIOLOGY
  • CHEMISTRY AND PHYSICS
  • MEDICINE
    • Cancer
    • Infectious Emerging Diseases
  • SPACE
  • TECHNOLOGY
  • CONTACT US
  • HOME PAGE
  • BIOLOGY
  • CHEMISTRY AND PHYSICS
  • MEDICINE
    • Cancer
    • Infectious Emerging Diseases
  • SPACE
  • TECHNOLOGY
  • CONTACT US
No Result
View All Result
Scienmag - Latest science news from science magazine
No Result
View All Result
Home SCIENCE NEWS Cancer

Cancer Core Europe’s design and development of data rich, dynamic studies in oncology

March 10, 2021
in Cancer
0
Share on FacebookShare on Twitter

Announcing the launch of an EU-funded, multi-site project: CCE Building Data Rich Clinical Trials (CCE-DART).

IMAGE

Credit: Cancer Core Europe

Spearheading next generation clinical trials: Cancer Core Europe’s design and development of data rich, dynamic studies in oncology

  • Incorporating experts from the seven European comprehensive cancer centers belonging to the Cancer Core Europe (CCE) Consortium, along with an additional four non-CCE partners*, the EU-funded, multi-site project CCE Building Data Rich Clinical Trials (CCE-DART), has now launched.
  • Coordinated by VHIO’s Elena Garralda, CCE-DART seeks to become a groundbreaking example in driving a novel generation of clinical trials in the current era of precision oncology.
  • This pioneering project will develop interconnected tools to reduce the current complexity of investigator-initiated trials and better guide clinical decision-making by incorporating cutting-edge digital technologies and platforms.

In the current era of precision medicine, the advent of novel, adaptive clinical studies including the so-called basket and umbrella clinical trials, among others, aim to address the current challenges in oncology including the globalization of clinical research, and the use and implementation of emerging health technologies.

While randomized controlled trials are considered the gold standard for studying the effectiveness of treatment approaches and anti-cancer therapies, they do not allow for the ‘real time’ and necessary adaptation in tune with the rapid pace of cancer discovery – especially in the academic setting.

To overcome this challenge, novel clinical trial designs promote the optimization of biomarker-drug co-development towards more precisely tailoring therapies to each disease setting, each individual patient. In short, these ‘smarter’ contenders seek to more effectively identify the optimal treatment for the right patient, at the right time, and promise to overcome the rigidity and limitations of traditional clinical trials.

The newly launched, EU-funded Cancer Core Europe Consortium-Building Data Rich Clinical Trials (CCE-DART) project is coordinated by VHIO’s Elena Garralda, Director of VHIO’s Research Unit for Molecular Therapy of Cancer (UITM) – “la Caixa” Foundation, and Principal Investigator of our Early Clinical Drug Development Group, and carried out in collaboration with other leading experts from within Cancer Core Europe Consortium*.

By harnessing and incorporating powerful cutting-edge technologies, methods and platforms, CCE-DART investigators will spur the design, development, and ringing in of a new generation of data rich, dynamic studies in oncology.

Building on the CCE-developed Basket of Baskets (BoB) investigator-initiated and adaptive trial which launched in 2018, CCE-DART will further enhance BoB’s harmonized, molecular multi-tier profiling platform to more precisely match patients to novel anti-cancer medicines based on the genetic specificities of their individual tumors. In parallel, the researchers will continue to develop multiple treatments in genomically-selected populations.

By introducing new tools -or adapting existing ones- the project will also seek to elevate the management and decision-making of clinical studies to the digital age, and ultimately represent a groundbreaking example for driving a new generation of clinical trials in by leveraging novel technologies within existing clinical structures.

“The wealth of expertise, cutting edge technologies, and clinical trial capabilities provided through CCE’s member centers and sites, along with our additional four partners, the Digital Experimental Cancer Medicine Team, The Hyve, DataRiver, and Form Vision, will enable us to fortify and further develop the BoB trial’s dynamic and highly adaptive design,” said Elena Garralda, Coordinator of the recently launched CCE-DART initiative.

“We will collectively seek to incorporate newer, more effective methods to the design, development and analysis of a new generation of data rich clinical trials, with particular emphasis on creating a sustainable framework for academic-led initiatives. As importantly, we are also dedicated to promoting and fostering the involvement of the cancer patient community in the design and implementation of our studies,” added Alejandro Piris, Head of VHIO’s Scientific Coordination Area at VHIO, who is coordinating the management and oversight of this present project.

Common infrastructures and the wealth of experience gained through CCE sites’ running of innovative academic studies, including the BoB study, will undoubtedly help the project partners to deliver on the four key objectives. Namely, to improve patient enrolment strategies and trial designs, accelerate the use of novel health technologies in the clinical setting, optimize clinical trial data management and analysis, and globalize the results of the project by promoting transparency of investigator-initiated studies.

“Supported by EU’s Horizon 2020 Framework Programme, CCE-DART will aim to elevate current networks and existing legal, technological and clinical infrastructures to further develop a new generation of methods and tools for more efficient, personalized, and effective clinical trials in oncology,” concluded Elena Garralda.

###

For more information about VHIO’s involvement in CCE-DART, please contact Amanda Wren, Head of the Director’s Office and Global Communications, Vall d´Hebron Institute of Oncology (VHIO): [email protected], Tel. +34 695207886.

* CCE Building Data Rich Clinical Trials (CCE-DART) Participants.

Cancer Core Europe (CCE) Consortium Members:

  • Vall d’Hebron Institute of Oncology, Barcelona, Spain.
  • Karolinska Institute, Stockholm, Sweden.
  • Cambridge Cancer Center, Cambridge, UK.
  • National Center for Tumor Diseases, Heidelberg, Germany.
  • Netherlands Cancer Institute, Amsterdam, The Netherlands.
  • National Cancer Institute of Milan, Italy.
  • Gustave Roussy Cancer Campus Grand Paris, Villejuif, France.

    Non-CCE Members:

  • Digital Experimental Cancer Medicine Team, Manchester, UK.
  • The Hyve, Utrecht, The Netherlands.
  • DataRiver, Modena, Italy.
  • Form Vision, Abcoude, The Netherlands.

    This project has received funding from the European Union’s Horizon 2020 framework programme research under grant agreement No: 965397

  • Media Contact
    Amanda Wren
    [email protected]

    Tags: cancerClinical TrialsHealth CareMedicine/Health
    Share25Tweet16Share4ShareSendShare
    • New imaging technology less accurate than MRI at detecting prostate cancer, trial shows

      66 shares
      Share 26 Tweet 17
    • Alcohol changes brain activity differently in male and female mice

      65 shares
      Share 26 Tweet 16
    • Scientists discover key to hepatitis A virus replication, show drug effectiveness

      65 shares
      Share 26 Tweet 16
    • Study explores coevolution of mammals and their lice

      65 shares
      Share 26 Tweet 16
    • COVID-19 fattens up our body’s cells to fuel its viral takeover

      95 shares
      Share 38 Tweet 24
    • Magnetic spins that ‘freeze’ when heated: Nature in the wrong direction

      65 shares
      Share 26 Tweet 16
    ADVERTISEMENT

    About us

    We bring you the latest science news from best research centers and universities around the world. Check our website.

    Latest NEWS

    nTIDE May 2022 COVID Update: Uncertainty about inflation tempers good news for people with disabilities

    COVID-19 fattens up our body’s cells to fuel its viral takeover

    The pair of Orcas deterring Great White Sharks – by ripping open their torsos for livers

    Subscribe to Blog via Email

    Enter your email address to subscribe to this blog and receive notifications of new posts by email.

    Join 190 other subscribers

    © 2022 Scienmag- Science Magazine: Latest Science News.

    No Result
    View All Result
    • HOME PAGE
    • BIOLOGY
    • CHEMISTRY AND PHYSICS
    • MEDICINE
      • Cancer
      • Infectious Emerging Diseases
    • SPACE
    • TECHNOLOGY
    • CONTACT US

    © 2022 Scienmag- Science Magazine: Latest Science News.

    Welcome Back!

    Login to your account below

    Forgotten Password?

    Retrieve your password

    Please enter your username or email address to reset your password.

    Log In
    Posting....