Can myeloid derived suppressor cells subdue viral infections?


Credit: ©Mary Ann Liebert, Inc., publishers

New Rochelle, NY, Jan. 26, 2017 — Myeloid derived suppressor cells (MDSCs), produced in the bone marrow as part of the human immune response to a tumor, may have a potent immunoregulatory role following viral infection. The similarities and differences between tumor-induced versus virus-induced MDSCs and the potential to use these cells for targeted immunotherapies are discussed in a review article in Viral Immunology, a peer-reviewed journal from Mary Ann Liebert, Inc., publishers. The article is available free on the Viral Immunology website.

In "The Role of Myeloid-Derived Suppressor Cells in Viral Infection," Megan O'Connor, Jessica Rastad, and William Green, Geisel School of Medicine at Dartmouth, Lebanon, NH, describe the MDSCs and MDSC-like cells found during viral infection. The authors discuss the mechanisms of MDSC immune suppression, the types of cells targeted, and the ability of MDSCs to directly alter the viral infectious process. They also report on the challenges in studying MDSC-mediated immunoregulation and the potential for developing antiviral therapies based on MDSC targeting.

"Our understanding of how MDSCs modulate the immune response to viral infections is still very limited. This review highlights the current state of knowledge regarding these important cells and considers how they might be harnessed therapeutically to attain a better balance of antiviral immunity and immunopathology," says David L. Woodland, PhD, Editor-in Chief of Viral Immunology and Chief Scientific officer for Keystone Symposia on Molecular and Cellular Biology.


Research reported in this publication was supported by grants from the National Institutes of Health under Award Numbers CA-50157, P30 GM10345, and T32 AI007363. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health.

About the Journal

Viral Immunology is an authoritative peer-reviewed journal published ten times a year in print and online. Topics cover both human and animal viral immunology, exploring viral-based immunological diseases, pathogenic mechanisms, and virus-associated tumor and cancer immunology. The Journal includes original research papers, review articles, and commentaries covering the spectrum of laboratory and clinical research and exploring developments in vaccines and diagnostics targeting viral infections. Tables of content and a sample issue may be viewed on the Viral Immunology website.

About the Publisher

Mary Ann Liebert, Inc., publishers is a privately held, fully integrated media company known for establishing authoritative peer-reviewed journals in many promising areas of science and biomedical research, including Journal of Interferon and Cytokine Research, AIDS Research and Human Retroviruses, and Biosecurity and Bioterrorism: Biodefense Strategy, Practice, and Science. Its biotechnology trade magazine, GEN (Genetic Engineering & Biotechnology News), was the first in its field and is today the industry's most widely read publication worldwide. A complete list of the firm's 80 journals, books, and newsmagazines is available on the Mary Ann Liebert, Inc., publishers website.

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