Wednesday, October 4, 2023
SCIENMAG: Latest Science and Health News
No Result
View All Result
  • Login
  • HOME PAGE
  • BIOLOGY
  • CHEMISTRY AND PHYSICS
  • MEDICINE
    • Cancer
    • Infectious Emerging Diseases
  • SPACE
  • TECHNOLOGY
  • CONTACT US
  • HOME PAGE
  • BIOLOGY
  • CHEMISTRY AND PHYSICS
  • MEDICINE
    • Cancer
    • Infectious Emerging Diseases
  • SPACE
  • TECHNOLOGY
  • CONTACT US
No Result
View All Result
Scienmag - Latest science news from science magazine
No Result
View All Result
Home SCIENCE NEWS Technology and Engineering

Bioengineers’ sweat sensor monitors glucose

October 13, 2016
in Technology and Engineering
0
Share on FacebookShare on Twitter
IMAGE

Credit: University of Texas at Dallas

Researchers at The University of Texas at Dallas are sweating the small stuff in their efforts to develop a wearable device that can monitor an individual's glucose level via perspiration on the skin.

In a study recently published online in the journal Sensors and Actuators B: Chemical, Dr. Shalini Prasad, professor of bioengineering in the Erik Jonsson School of Engineering and Computer Science, and her co-authors demonstrated the capabilities of a biosensor they designed to reliably detect and quantify glucose in human sweat.

The team has previously demonstrated that their technology can detect cortisol in perspiration.

But for diabetics and those at risk for diabetes, self-monitoring of blood glucose, or blood sugar, is an important part of managing their conditions.

"Fitness trackers that monitor heart rate and step count are very popular, but wearable, non-invasive biosensors would be extremely beneficial for managing diseases," said Prasad, the Cecil H. and Ida Green Professor in Systems Biology Science.

Typical home-use blood glucose monitors require a user to obtain a small blood sample, usually through the prick of a finger and often several times a day. However, the UT Dallas textile-based sensor detects glucose in the small amount of ambient sweat on a person's skin.

"In our sensor mechanism, we use the same chemistry and enzymatic reaction that are incorporated into blood glucose testing strips," Prasad said. "But in our design, we had to account for the low volume of ambient sweat that would be present in areas such as under a watch or wrist device, or under a patch that lies next to the skin."

Prasad said that researchers who work with sweat often use a process called iontophoresis, which sends an electric current through the skin to generate enough perspiration for sensing experiments. However, because this method can lead to rashes and burns on the skin, the team sought an alternative that would work with small amounts of sweat.

Their design works with volumes of sweat less than a microliter, which is the approximate amount of liquid that would fit in a cube the size of a salt crystal.

The technology also provides a real-time response in the form of a digital readout.

Prasad and bioengineering doctoral student Rujuta Munje, lead author of the journal article, incorporated an off-the-shelf polymer-based textile material in their glucose sensor and used UT Dallas clean-room facilities to construct the electronic elements. The prototype is a small, flexible, rod-shaped device about an inch long.

"We used known properties of textiles and weaves in our design," Prasad said. "What was innovative was the way we incorporated and positioned the electrodes onto this textile in such a way that allows a very small volume of sweat to spread effectively through the surface."

Typical blood glucose testing strips also contain a molecule that ultimately amplifies the signal from the chemical reactions on the strip enough to register electronically on a monitoring device. But if used in a device that is worn next to the skin, those molecules can be irritating, Prasad said, which presented another challenge.

To ensure that such a tiny amount of sweat would generate a strong enough signal, Prasad and Munje modified the surface topography of the textile material.

"Our modifications allow this material to entrap glucose oxidase molecules, which effectively amplifies the signal," Prasad said. "We did it this way because we are thinking about possible commercialization — to make these, we need a fabrication process that is not complex."

Prasad and Munje also were able to account for the fact that the chemistry of a person's sweat changes throughout the day.

"Glucose is a tricky molecule to monitor because other factors can confound a signal," Prasad said. "For example, the pH, or acidity, of your sweat can vary greatly depending on the circumstances."

She noted that when individuals exercise or are under stress, the level of other compounds in their sweat, such as cortisol and lactic acid, change as well, and these can interfere with glucose detection.

"We have shown that with our technology, we address three critical issues: low volume of ambient sweat, interference from other compounds and pH swings," Prasad said

Prasad and Munje tested their prototype using samples of human sweat from donors.

While a consumer product based on the technology is still a few years away, the concept was developed with commercialization and scaled-up production in mind.

"At this point, we are thinking of this sensor as something you use for a day and toss out, and we believe it could easily be incorporated into existing consumer electronics platforms," Prasad said. "We're very excited about the potential for licensing this technology."

The research was supported by the Cecil H. and Ida Green endowed fellowship at UT Dallas.

Researchers at UT Dallas and elsewhere have investigated whether glucose found in other bodily fluids — such as urine and tears — might be used to track glucose levels, further eliminating the need for invasive blood draws. Google, for example, is investigating a smart contact lens designed to measure glucose levels in tears.

The Centers for Disease Control and Prevention estimate that 29 million people in the United States have diabetes and 86 million have prediabetes.

###

Media Contact

Amanda Siegfried
amanda.siegfried@utdallas.edu
972-883-4335
@ut_dallas

http://www.utdallas.edu

Share25Tweet16Share4ShareSendShare
  • New $81million NIH grant will help U.S. answer urgent need for better dementia care

    72 shares
    Share 29 Tweet 18
  • New research finds that ancient carbon in rocks releases as much carbon dioxide as the world’s volcanoes

    70 shares
    Share 28 Tweet 18
  • IU cancer researcher receives $2.2 million grant for metastatic breast cancer research

    70 shares
    Share 28 Tweet 18
  • Instant evolution: AI designs new robot from scratch in seconds

    69 shares
    Share 28 Tweet 17
  • The World Mitochondria Society will host Targeting Mitochondria 2023 with challenging visions in Berlin

    66 shares
    Share 26 Tweet 17
  • Pumped for frigid weather: study pinpoints cold adaptations in nervous system of Antarctic octopus

    70 shares
    Share 28 Tweet 18
ADVERTISEMENT

About us

We bring you the latest science news from best research centers and universities around the world. Check our website.

Latest NEWS

Null results research now published by major behavioral medicine journal

Groundbreaking mathematical proof: new insights into typhoon dynamics unveiled

New $81million NIH grant will help U.S. answer urgent need for better dementia care

Subscribe to Blog via Email

Enter your email address to subscribe to this blog and receive notifications of new posts by email.

Join 208 other subscribers

© 2023 Scienmag- Science Magazine: Latest Science News.

No Result
View All Result
  • HOME PAGE
  • BIOLOGY
  • CHEMISTRY AND PHYSICS
  • MEDICINE
    • Cancer
    • Infectious Emerging Diseases
  • SPACE
  • TECHNOLOGY
  • CONTACT US

© 2023 Scienmag- Science Magazine: Latest Science News.

Welcome Back!

Login to your account below

Forgotten Password?

Retrieve your password

Please enter your username or email address to reset your password.

Log In