Beta blockers may lead to new novel triple negative breast cancer treatments
New research published in the March 2016 issue of The FASEB Journal, shows that a commonly prescribed class of high blood pressure drugs may have the potential to slow the growth of triple negative breast cancer tumors. These drugs, called "beta blockers" work by counteracting the pro-growth effect caused by adrenaline by affecting the the beta2-adrenoceptor.
"Previous studies have linked increased stress with accelerated onset of metastasis in some forms of breast cancer," said Michelle L. Halls, Ph.D., a researcher involved in the work from the Drug Discovery Biology Theme at Monash Institute of Pharmaceutical Sciences at Monash University in Parkville, Victoria, Australia. "By understanding how stress accelerates invasion in aggressive breast tumor cells, this work will inform future studies into whether beta-blockers could be a useful adjuvant therapy in the treatment of some aggressive breast cancers."
To make their discovery, Halls and colleagues examined how an aggressive triple negative breast cancer cell responds to the stress hormone adrenaline. They found that an aggressive breast cancer tumor cell has a cell surface protein called "beta2-adrenoceptor" that can binds both beta-blockers and the stress hormone adrenaline. When bound to adrenaline, the beta2-adrenoceptor on these tumor cells stimulates a positive signaling loop to accelerate invasion. When bound to beta-blocker, however, the accelerated invasion of these cells was decreased.
"This is excellent research that shows us that we still do not know the full potential of many of the drugs sitting in most medicine cabinets," said Thoru Pederson, Ph.D., Editor-in-Chief of The FASEB Journal. "Not only does this shed light on how to potentially improve the effectiveness of triple negative cancer treatments, but it also sheds light on the full effect that these common drugs have on our bodies."
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Details: Cindy K. Pon, J. Robert Lane, Erica K. Sloan, and Michelle L. Halls The β2-adrenoceptor activates a positive cAMP-calcium feedforward loop to drive breast cancer cell invasion. FASEB J. March 2016 30:1144-1154; doi: 10.1096/fj.15-277798. http://www.fasebj.org/content/30/3/1144.abstract ; Early online version: November 17, 2015. Final version: March 1, 2016.