BASF and UC Davis collaborating to unlock new potential in human milk oligosaccharides

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Credit: Lisa Howard, UC Davis

FLORHAM PARK, NJ and DAVIS, CA, July 25, 2018 – BASF and the University of California, Davis (UC Davis) announced a collaboration to unlock new benefits of human milk oligosaccharides (HMOs). The long-term objective of this strategic research partnership is to develop and validate second-generation HMO molecules as potent bioactive compounds that can influence the establishment and maintenance of the gut microbiome and provide benefits beyond the gastrointestinal tract, such as brain health, for infants, children and adults.

Human milk contains a multitude of HMOs, a class of indigestible carbohydrates that is gaining recognition for a variety of health-promoting activities. Substantial evidence demonstrates that the high diversity of structures and concentration of HMOs in human milk contribute to improved health outcomes associated with breastfeeding.

BASF recently announced the launch of 2'-fucosyllactose (2'-FL) for infant nutrition and is now taking next steps to expand its scientific and application know-how in the area of HMOs.

"This collaboration is an essential cornerstone of our strategic initiative to become a leading science-based player in the fields of HMO and microbiome," said Stefan Rüdenauer, Director of Development and Scientific Marketing Human Nutrition, BASF.

The two-year partnership with UC Davis' research team is part of BASF's California Research Alliance (CARA), which brings together experts from major universities on the West Coast to collaborate on new materials and their applications, biosciences and related technologies. Professors Daniela Barile, David Mills, Helen Raybould, Xi Chen, and Bruce German from the Foods for Health Institute at UC Davis will use their collective expertise to reveal new applications for HMOs. BASF's contributions to the partnership include its proficiency in fermentation products and the development of human nutrition solutions, as well as project funding.

"We are excited to partner with BASF to unlock novel HMO functionalities," said Professor Barile. "This project will employ a range of microbiological and physiological studies employing cutting-edge glycomics and metagenomics tools to explore how HMOs interact with the human host and the microbes within them."

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For a press photo, please click the following link:

https://www.basf.com/press-photos/us/en/photos/2018/07/07-25-18_BASF_UC_Davis.jpg

Suggested caption: Representatives from BASF and UC Davis recently signed a collaboration agreement expressing their mutual commitment to unlocking new potential for human milk oligosaccharides (HMOs). Front, left to right: Prasant Mohapatra (UC Davis), Benjamin Knudsen (BASF), Ahmad Hakim-Elahi (UC Davis), Stefan Rüdenauer (BASF), Dushyant Pathak (UC Davis).

Back, left to right: Marianne Heer (BASF), Anita Oberbauer (UC Davis), David Mills (UC Davis), Yan Qin (BASF), Helen Raybould (UC Davis), Daniela Barile (UC Davis), Yoram Barak (BASF), Bruce German (UC Davis), Xi Chen (UC Davis).

  <p><strong>About BASF</strong>  

BASF Corporation, headquartered in Florham Park, New Jersey, is the North American affiliate of BASF SE, Ludwigshafen, Germany. BASF has more than 18,200 employees in North America, and had sales of $17.9 billion in 2017. For more information about BASF's North American operations, visit http://www.basf.com.

At BASF, we create chemistry for a sustainable future. We combine economic success with environmental protection and social responsibility. The more than 115,000 employees in the BASF Group work on contributing to the success of our customers in nearly all sectors and almost every country in the world. Our portfolio is organized into five segments: Chemicals, Performance Products, Functional Materials & Solutions, Agricultural Solutions and Oil & Gas. BASF generated sales of €64.5 billion in 2017. BASF shares are traded on the stock exchanges in Frankfurt (BAS), London (BFA) and Zurich (BAS). Further information at http://www.basf.com.

About CARA

The California Research Alliance (CARA) is one of four BASF scientific excellence clusters that collaborate with research groups on a regional level, maintaining a network between BASF, the campuses of the University of California system, Stanford and Caltech. The researchers at CARA work in a variety of scientific disciplines including new materials, biosciences, formulations, and catalysis, as well as computational and engineering disciplines.

The CARA collaboration, started in 2014 with 10 postdoctoral positions, has been extended to approximately 50 postdoctoral positions today. CARA researchers have filed 10 patents, and have had more than 20 peer-reviewed papers accepted or published. In addition, the first research projects have already been transferred to BASF R&D for further development. Peidong Yang, CARA Co-Director and Professor of Chemistry at UC Berkeley, said, "With this newest collaboration, we now have multiple CARA research projects active between BASF, the UC campuses, Stanford, and Caltech. The broad research expertise represented by this vibrant West Coast scientific community will surely expedite the discovery process for many scientific and technological questions."

                           <p><strong>Media Contact</strong></p>    <p>Betsy Arnone<br />[email protected]<br />973-245-7865<br />

http://www.basf.com

       <h4>Original Source</h4>https://www.basf.com/us/en/company/news-and-media/news-releases/2018/07/P-US-18-080.html 
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