Alzheimer's disease biomarker identified across test sites
New Rochelle, NY, September 12, 2017–A new study has demonstrated the potential to use a frequency distribution-based index of brain functional connectivity as a biomarker for detecting Alzheimer's disease and mild cognitive impairment (MCI). These new findings, which show the index of functional connectivity to have good accuracy across databases and test sites, are published in Brain Connectivity, a peer-reviewed journal from Mary Ann Liebert, Inc., publishers. The article is available free on the Brain Connectivity website until October 13, 2017.
The article entitled "Can a Resting-State Functional Connectivity Index Identify Patients with Alzheimer's Disease and Mild Cognitive Impairment Across Multiple Sites?" was coauthored by Keiichi Onoda and colleagues from Shimane University (Japan), representing the Alzheimer's Disease Neuroimaging Initiative (ADNI). The researchers compared multi-variant pattern analysis (MVPA) and a frequency distribution-based index approach to evaluate functional connectivity and determine which method yielded consistent results across two different databases and sites that were part of the ADNI.
"Dr. Onoda and colleagues are among the first researchers to test the predictive power of their computer image analysis methods to detect Alzheimer's disease and mild cognitive impairment on several large publicly available imaging databases," states Christopher Pawela, PhD, Editor-in-Chief of Brain Connectivity and Assistant Professor, Medical College of Wisconsin. "The potential for any imaging biomarker to find widespread clinical usage depends on its ability to predict disease correctly in a large number of subjects. These researchers have made progress towards this goal by developing a biomarker that shows promise in these large imaging databases."
Research reported in this publication was supported by the National Institutes of Health under Award Number U01 AG024904. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health.
About the Journal
Brain Connectivity is the essential peer-reviewed journal covering groundbreaking findings in the rapidly advancing field of connectivity research at the systems and network levels. Published 10 times per year in print and online, the Journal is under the leadership of Founding and Co-Editors-in-Chief Christopher Pawela, PhD, Assistant Professor, Medical College of Wisconsin, and Bharat Biswal, PhD, Chair of Biomedical Engineering, New Jersey Institute of Technology. It includes original peer-reviewed papers, review articles, point-counterpoint discussions on controversies in the field, and a product/technology review section. To ensure that scientific findings are rapidly disseminated, articles are published Instant Online within 72 hours of acceptance, with fully typeset, fast-track publication within 4 weeks. Tables of content and a sample issue may be viewed on the Brain Connectivity website.
About the Publisher
Mary Ann Liebert, Inc., publishers is a privately held, fully integrated media company known for establishing authoritative medical and biomedical peer-reviewed journals, including Journal of Neurotrauma and Therapeutic Hypothermia and Temperature Management. Its biotechnology trade magazine, GEN (Genetic Engineering & Biotechnology News), was the first in its field and is today the industry's most widely read publication worldwide. A complete list of the firm's 80 journals, newsmagazines, and books is available on the Mary Ann Liebert, Inc., publishers website.