Saturday, May 27, 2023
SCIENMAG: Latest Science and Health News
No Result
View All Result
  • Login
  • HOME PAGE
  • BIOLOGY
  • CHEMISTRY AND PHYSICS
  • MEDICINE
    • Cancer
    • Infectious Emerging Diseases
  • SPACE
  • TECHNOLOGY
  • CONTACT US
  • HOME PAGE
  • BIOLOGY
  • CHEMISTRY AND PHYSICS
  • MEDICINE
    • Cancer
    • Infectious Emerging Diseases
  • SPACE
  • TECHNOLOGY
  • CONTACT US
No Result
View All Result
Scienmag - Latest science news from science magazine
No Result
View All Result
Home SCIENCE NEWS Technology and Engineering

Advancing diagnostics for lupus nephritis

May 4, 2022
in Technology and Engineering
0
Share on FacebookShare on Twitter

The nature of a typical clinical test for lupus nephritis (LN), an inflammation of the kidneys and a leading cause of mortality in lupus patients, is fraught with difficulty. The invasive renal biopsy can be painful and may cause kidney damage. Unfortunately, 60% of patients with the often-disabling autoimmune disorder systemic lupus erythematosus (SLE) will face this burden as they advance into potentially fatal lupus nephritis.    

Tianfu Wu, University of Houston associate professor of biomedical engineering

Credit: University of Houston

The nature of a typical clinical test for lupus nephritis (LN), an inflammation of the kidneys and a leading cause of mortality in lupus patients, is fraught with difficulty. The invasive renal biopsy can be painful and may cause kidney damage. Unfortunately, 60% of patients with the often-disabling autoimmune disorder systemic lupus erythematosus (SLE) will face this burden as they advance into potentially fatal lupus nephritis.    

“Given the heterogenetic nature and unmet needs in precision diagnosis and classification of SLE/LN patients for personalized medication, identification of novel biomarkers, particularly in the form of a biomarker panel, is of paramount importance,” reports Tianfu Wu, University of Houston associate professor of biomedical engineering, in the journal Frontiers in Immunology.  

So, Wu and his team met that need using the large-scale study of proteins involved in the immune system, known as immunoproteomics, combined with bioinformatics, which combines gene expression data with computer storage and analysis.  

A total of 300 immunoglobulin-binding proteins were discovered in the screening, among which 77 proteins were detectable only in LN samples. Bioinformatics-assisted selection allowed the team to further identify ten potential immunoglobulin-binding proteins, which form circulating immune complexes (ICx) as potential biomarkers in LN. 

“Immunoproteomics-based discovery studies have enabled us to identify promising immune complexes in LN, which are associated with clinical parameters including renal pathology indices,” said Wu. “These ICx may be useful for the development of more accurate and clinical blood tests for this disease and if validated, this test may be able to replace the existing invasive tests at some point.” 

The first author of the article is Chenling Tang, a doctoral student in Wu’s lab. Other collaborators include Min Fang, Gongjun Tan, Shu Zhang, Bowen Yang, Yaxi Li1, Ting Zhang and Chandra Mohan from the University of Houston and Ramesh Saxena, University of Texas Southwestern Medical Center in Dallas. 



Journal

Frontiers in Immunology

Article Title

Discovery of Novel Circulating Immune Complexes in Lupus Nephritis Using Immunoproteomics

Article Publication Date

22-Mar-2022

Tags: advancingDiagnosticslupusnephritis
Share26Tweet16Share4ShareSendShare
  • IMAGE

    A new synthesis method for three-dimensional nanocarbons

    64 shares
    Share 26 Tweet 16
  • Within just a few months a deadly epidemic killed all the black sea urchins in the Gulf of Eilat – a great threat to the coral reef in Eilat

    68 shares
    Share 27 Tweet 17
  • How eating natto might help to distress

    64 shares
    Share 26 Tweet 16
  • GPS tracking reveals how a female baboon stopped using urban space after giving birth

    64 shares
    Share 26 Tweet 16
  • Promising building blocks for photonic quantum simulators

    64 shares
    Share 26 Tweet 16
  • Study highlights long-term benefits of family-based care following institutional care

    65 shares
    Share 26 Tweet 16
ADVERTISEMENT

About us

We bring you the latest science news from best research centers and universities around the world. Check our website.

Latest NEWS

Society for Cardiovascular Angiography and Interventions bestows highest designation ranking to leading interventional cardiologists

SCAI announces new award recognizing the contributions of early career interventional cardiologists

Study finds cardiovascular risk score improves after one year of semaglutide use in patients with overweight and obesity

Subscribe to Blog via Email

Enter your email address to subscribe to this blog and receive notifications of new posts by email.

Join 206 other subscribers

© 2023 Scienmag- Science Magazine: Latest Science News.

No Result
View All Result
  • HOME PAGE
  • BIOLOGY
  • CHEMISTRY AND PHYSICS
  • MEDICINE
    • Cancer
    • Infectious Emerging Diseases
  • SPACE
  • TECHNOLOGY
  • CONTACT US

© 2023 Scienmag- Science Magazine: Latest Science News.

Welcome Back!

Login to your account below

Forgotten Password?

Retrieve your password

Please enter your username or email address to reset your password.

Log In