A diet of high-iron beans improves health of anemic women in Rwanda

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An 18-week diet of high-iron beans improved the physical performance of women at a university in Rwanda. The study shows the potential of biofortified crops to address nutritional deficiencies in low-income countries

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Credit: HarvestPlus

Anemia is a global health problem common in low-income countries. Severe cases can lead to fatigue, heart problems, and complications in pregnancy. When widespread, anemia can also weigh on national economies.

Anemia’s leading cause is iron deficiency. Unfortunately, iron supplements or diet diversification is not always an option for addressing anemia for the rural poor. Enhancing the iron content of farm-grown staples like beans may be a sustainable, inexpensive, and effective alternative, research shows.

A new study involving women of reproductive age in Rwanda, where 19% of that demographic is anemic, showed that a diet including high-iron beans can improve iron status and physical performance relatively quickly.

Published in the Journal of Nutrition in January, researchers say the study is the first food intervention to demonstrate that changes in hemoglobin or ferritin – indicators of blood iron levels – from consuming iron-enhanced beans twice a day (as traditionally consumed) improves work efficiency in iron-deficient women.

“Our study found that the increases in markers of iron status in women who consumed the iron-biofortified beans led to improvements in their work efficiency,” said Mercy Lung’aho, a co-author at the Alliance of Bioversity International and CIAT.

Iron-biofortified beans are varieties that are conventionally bred – meaning they are not genetically modified – to contain higher levels of iron. Consumption of biofortified crops is promoted by HarvestPlus, which is part of the CGIAR Research Program on Agriculture for Nutrition and Health (A4NH).

“This is the first study to show an effect of a food-based intervention on moderate levels of physical work capacity,” said Jere D. Haas, a co-author and Emeritus Professor of Nutrition at Cornell University.

Haas said previous studies involving iron supplements had shown that improving iron status in iron-deficient adults can improve their ability to perform heavy work.

The study builds on previous research in Rwanda that showed consumption of iron-biofortified beans was also linked to improved cognitive function in adult women.

Biofortified benefits

The Rwanda study included 125 female college students ages 18 to 26 who had depleted iron stores but were otherwise healthy. The subjects were randomly assigned to either a group that received iron-biofortified beans or one that received non-biofortified beans.

The women in both groups received two meals a day over 18 weeks. Those who ate iron-biofortified beans, and whose hemoglobin (a measure of anemia) or iron status improved, exhibited a significant reduction in the energy needed to perform light physical work, such as walking, cleaning or other household chores.

In sub-Saharan Africa, 37% of women are anemic and nearly one in three cases is caused by iron deficiency. Iron-biofortified beans, currently available in 14 countries, contain up to twice the amount of iron as other common bean varieties. When eaten twice daily, these beans can provide up to 80% of daily iron needs.

“Common beans are an important source of multiple nutrients and health-promoting phytochemicals in several low- and middle-income countries where iron deficiency remains a public health problem,” said Erick Boy, Head of Nutrition at HarvestPlus.

“This study confirms that not only can biofortified beans effectively build up young women’s iron stores to ensure healthy future pregnancies, but also that regular consumption can potentially help women derive greater productivity from paid physical work (e.g., in agriculture) and not get physically fatigued as easily,” Boy said.

HarvestPlus, in collaboration with multiple partners, promotes high-iron beans and several other biofortified staple crops in countries worldwide. By the end of 2018, 1 in 5 bean growers in Rwanda grew biofortified beans, which are also high-yielding, disease-resistant, and tolerant of heat and drought.

“As suggested by the economic studies from China and South Asia, improvements in worker efficiency from resolving iron deficiency could lead to significant improvements in other aspects of workers’ lives and communities,” said Lung’aho. “As biofortification targets low-resource individuals, who often rely on manual labor for sustenance, our study’s demonstrated improvements in physical work efficiency have the potential to make a truly meaningful impact on their daily lives and productivity.”

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In memoriam

The co-authors and their institutions would like to acknowledge Sarah V. Luna, the principal author of this study, who passed away tragically on May 20, 2019. She diligently contributed to the laboratory and fieldwork, data analysis, and the initial draft of the article. Highlighting this research is an homage to her lifelong commitment to excellence in academia and service to others.

About the Alliance

The Alliance of Bioversity International and the International Center for Tropical Agriculture (CIAT) delivers research-based solutions that harness agricultural biodiversity and sustainably transform food systems to improve people’s lives. Alliance solutions address the global crises of malnutrition, climate change, biodiversity loss, and environmental degradation. The Alliance is part of CGIAR, a global research partnership for a food-secure future. http://www.bioversityinternational.org http://www.ciat.cgiar.org http://www.cgiar.org

About HarvestPlus

HarvestPlus improves nutrition and public health by developing and promoting biofortified food crops that are rich in vitamins and minerals and providing global leadership on biofortification evidence and technology. HarvestPlus is part of the CGIAR Research Program on Agriculture for Nutrition and Health (A4NH) and is coordinated by the International Food Policy Research Institute (IFPRI). HarvestPlus works with several CGIAR research centers to breed biofortified crops.

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Related Journal Article

http://dx.doi.org/10.1093/jn/nxaa016

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